Anticorps Polyclonal de lapin anti-C13orf3

C13orf3 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 26320-1-PBS

Synonymes

RAMA1, SKA3, Spindle And Kinetochore Associated Complex Subunit 3, Spindle and kinetochore-associated protein 3

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Galerie de données de validation

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  WB analysis using 26320-1-AP (same clone as 26320-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 26320-1-AP (C13orf3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26320-1-PBS in a different storage buffer formulation.

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Informations sur le produit

26320-1-PBS cible C13orf3 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: C13orf3 Protéine recombinante Ag23684
• Nom complet: chromosome 13 open reading frame 3
• Poids moléculaire observé: 54 kDa
• Numéro d’acquisition GenBank: BC048988
• Symbole du gène: C13orf3
• Identification du gène (NCBI): 221150
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

C13orf3 (now known as Ska3) is a component of a spindle- and mitophore-associated protein complex that regulates microtubule attachment to the mitophore during mitosis. Ska3 is localized to the outer side of the mitophore during mitosis and may be essential for normal chromosome segregation. In addition, deletion of Ska3 results in a delay in mid-mitotic division and an inability to silence the spindle checkpoint or enter prophase. Accumulation of Ska3 is dependent on Sgo1 proteins, whereas mitotic accumulation of Sgo1 in prophase is not dependent on Ska3. The discovery of Ska3 further refines the function of the Ska complex, which plays an important role in mitotic progression and chromosome segregation. The discovery of Ska3 in the prophase of Sgo1 is a key factor in mitosis and chromosome segregation.

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