Anticorps Polyclonal de lapin anti-C1orf112

C1orf112 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27863-1-PBS

Synonymes

APOLO1, FIDGETIN-like-1 interacting protein, FIGNL1 Interacting Regulator Of Recombination And Mitosis, FIGNL1-interacting regulator of recombination and mitosis, FIRRM

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Galerie de données de validation

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  WB analysis using 27863-1-AP (same clone as 27863-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27863-1-AP (C1orf112 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27863-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27863-1-PBS cible C1orf112 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: C1orf112 Protéine recombinante Ag27316
• Nom complet: chromosome 1 open reading frame 112
• Masse moléculaire calculée: 853 aa, 97 kDa
• Poids moléculaire observé: 98 kDa
• Numéro d’acquisition GenBank: BC107168
• Symbole du gène: C1orf112
• Identification du gène (NCBI): 55732
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FIRRM (Fanconi anemia pathway and RAD51-mediated DNA repair regulator, also known as C1orf112 or FLIP) is an evolutionarily conserved protein involved in DNA damage repair and homologous recombination. It ensures DNA cross-link (ICL) repair and genomic stability by regulating RAD51 activity. FIRRM expression is upregulated in a variety of tumors and correlates with poor prognosis. Its dysfunction leads to increased genomic instability, as evidenced by enhanced DNA damage signaling, chromosomal abnormalities, and micronucleus formation. The study of FIRRM is important for understanding the mechanisms of tumorigenesis and developing new therapeutic strategies.

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