Anticorps Polyclonal de lapin anti-C8G

C8G Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27200-1-PBS

Synonymes

C8C

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Galerie de données de validation

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  WB analysis using 27200-1-AP (same clone as 27200-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27200-1-AP (C8G antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

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  WB analysis of human placenta using 27200-1-AP (same clone as 27200-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 27200-1-AP (C8G antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 27200-1-AP (same clone as 27200-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27200-1-AP (C8G antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 27200-1-AP (same clone as 27200-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 27200-1-AP (C8G antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 27200-1-AP (same clone as 27200-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27200-1-AP (C8G antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 27200-1-AP (same clone as 27200-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 27200-1-AP (C8G antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27200-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27200-1-PBS cible C8G dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: C8G Protéine recombinante Ag17949
• Nom complet: complement component 8, gamma polypeptide
• Masse moléculaire calculée: 202 aa, 22 kDa
• Poids moléculaire observé: 18-22 kDa
• Numéro d’acquisition GenBank: BC113626
• Symbole du gène: C8G
• Identification du gène (NCBI): 733
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The gamma chain of complement component 8 (C8G) is one of three different subunits (alpha, beta, and gamma) of the eighth complement component (C8), which is a component of the MAC (membrane attack complex) (PMID:33382892). Although the roles of C8A and C8B are directly associated with MAC formation, C8G is not essential in the assembly and activity of the MAC (PMID:11960635). Moreover, C8G was shown to inhibit neuroinflammation by interfering with the sphingosine-1-phosphate (S1P)-S1PR2 interaction (PMID:34149451).

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