Anticorps Recombinant de lapin anti-CA2

CA2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242559B4

N° de cat : 84954-4-PBS

Synonymes

Car2, CA-II, CAII, CAC, CA II

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Galerie de données de validation

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  WB analysis using 84954-4-RR (same clone as 84954-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84954-4-RR (CA2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84954-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84954-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84954-4-RR against Human CA2 were performed. The affinity constant is 23.5 nM.

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Informations sur le produit

84954-4-PBS cible CA2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CA2 Protéine recombinante Ag10680
• Nom complet: carbonic anhydrase II
• Masse moléculaire calculée: 260 aa, 29 kDa
• Poids moléculaire observé: 29 kDa
• Numéro d’acquisition GenBank: BC011949
• Symbole du gène: CA2
• Identification du gène (NCBI): 760
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CA2(carbonic anhydrase II ) is also called Car2, CA-II, and CAII and belongs to the alpha-carbonic anhydrase family. It reversibly hydrates CO2 in cellular ion transport and homeostasis. CA2 is essential for bone resorption and osteoclast differentiation. It regulates SLC9A1 activity via a phosphorylation-regulated CAII binding site in SLC9A1 tail(PMID:16475831). It also may be involved in brain development (PMID:16825953). Defects in CA2 cause osteopetrosis autosomal recessive type 3 (OPTB3).

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