Anticorps Polyclonal de lapin anti-CACNA1H

CACNA1H Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28092-1-PBS

Synonymes

CACNA1HB, Cav3.2, EIG6, FLJ90484, Low-voltage-activated calcium channel alpha1 3.2 subunit

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Galerie de données de validation

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  WB analysis using 28092-1-AP (same clone as 28092-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28092-1-AP (CACNA1H antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28092-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28092-1-PBS cible CACNA1H dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CACNA1H Protéine recombinante Ag26094
• Nom complet: calcium channel, voltage-dependent, T type, alpha 1H subunit
• Masse moléculaire calculée: 259 kDa
• Poids moléculaire observé: 259 kDa
• Numéro d’acquisition GenBank: NM_001005407
• Symbole du gène: CACNA1H
• Identification du gène (NCBI): 8912
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) is located in the plasma membrane of various tissues, including the brain cortex, amygdala, caudate nucleus, putamen, kidney, liver, and heart. This subunit regulates muscle contraction, secretion, neurotransmission, and gene expression by forming the pore (PMID: 33985586). Predominantly, the changes observed are missense mutations associated with gain-of-function, resulting in an increased influx of calcium into adrenal cells (PMID: 33985586; 37311830).

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