Anticorps Polyclonal de lapin anti-CACNA2D4

CACNA2D4 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 26674-1-PBS

Synonymes

RCD4, Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-dependent calcium channel subunit alpha-2-4, Voltage-dependent calcium channel subunit delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4

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Galerie de données de validation

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  WB analysis using 26674-1-AP (same clone as 26674-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 26674-1-AP (CACNA2D4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26674-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 26674-1-AP (same clone as 26674-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26674-1-AP (CACNA2D4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26674-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 26674-1-AP (same clone as 26674-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26674-1-AP (CACNA2D4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26674-1-PBS in a different storage buffer formulation.

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Informations sur le produit

26674-1-PBS cible CACNA2D4 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CACNA2D4 Protéine recombinante Ag24464
• Nom complet: calcium channel, voltage-dependent, alpha 2/delta subunit 4
• Masse moléculaire calculée: 1137 aa, 128 kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: BC150186
• Symbole du gène: CACNA2D4
• Identification du gène (NCBI): 93589
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Calcium voltage-gated channel auxiliary subunit alpha2delta 4 (CACNA2D4, also known as RCD4) is a member of the alpha-2/delta subunit family within the voltage-dependent calcium channel complex. The α2δ4 subunit of retinal voltage-gated calcium channels (Cav), is crucial for developing and mature exocytotic function of the photoreceptor ribbon synapse (PMID: 29875267). CACNA2D4 is localized to the retina, particularly in photoreceptors, where it is essential for organizing synaptic ribbons and setting Cav1.4 voltage sensitivity (PMID: 28262416). In humans, mutations in CACNA2D4 are associated with autosomal recessive cone dystrophy, a condition that affects the photoreceptor cells in the retina (PMID: 16877424).

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