Anticorps Polyclonal de lapin anti-CAMSAP1

CAMSAP1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18816-1-PBS

Synonymes

PRO2405, Calmodulin-regulated spectrin-associated protein 1

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Galerie de données de validation

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  WB analysis using 18816-1-AP (same clone as 18816-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18816-1-AP (CAMSAP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18816-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18816-1-PBS cible CAMSAP1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: calmodulin regulated spectrin-associated protein 1
• Masse moléculaire calculée: 179 kDa
• Poids moléculaire observé: 245 kDa
• Numéro d’acquisition GenBank: BC144082
• Symbole du gène: CAMSAP1
• Identification du gène (NCBI): 157922
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CAMSAP1, or Calmodulin-regulated spectrin-associated protein 1, is a protein that plays a crucial role in the formation and maintenance of the minus end of non-centrosomal microtubules, which are essential for proper neuronal function and development. Research has shown that CAMSAP1 is vital for neuronal polarization, migration, and cortical lamination. CAMSAP1 has also been implicated in cancer prognosis. A study found that CAMSAP1 mutation can activate anti-tumor immunity, mediate tumor cell apoptosis, inhibit epithelial-mesenchymal transition (EMT), improve prognosis, and improve platinum drug sensitivity in small-cell lung cancer patients treated with platinum-based chemotherapy, suggesting that CAMSAP1 mutation may be a potential biomarker indicating platinum drug sensitivity and patient prognosis. The CAMSAP1 of the calculated MW is around 170 kDa, and the observed MW is 245 kDa (PMID: 32839317).

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