Anticorps Polyclonal de lapin anti-Caspase 14

Caspase 14 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28136-1-PBS

Synonymes

CASP14, CASP 14, Caspase-14 subunit p10, mature form, Caspase-14, Caspase14

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Galerie de données de validation

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  WB analysis using 28136-1-AP (same clone as 28136-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28136-1-AP (Caspase 14 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28136-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28136-1-PBS cible Caspase 14 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Caspase 14 Protéine recombinante Ag27242
• Nom complet: caspase 14, apoptosis-related cysteine peptidase
• Masse moléculaire calculée: 242 aa, 28 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: BC069541
• Symbole du gène: CASP14
• Identification du gène (NCBI): 23581
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Caspase14 belongs to the caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspase14 exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits (p20 and p10) at Ile152/Lys153 residues, which is different to other caspases (Asp residue). Caspase14 plays a role in protein maturation of filaggrin, and possibly in DNA repair. Overexpression of Caspase14 has been detected in several of epithelial malignancies, indicating that Caspase14 could play a role in carcinogenesis and disease progression of cancers. Caspase14 can binds the apoptosis-inducing factor (AIF) indicating that caspase14 may be an anti-apoptotic protein. In the LADC specimens, two bands can be detected with MW of 35 kDa and 37 kDa which represent Caspase14 and the phosphorylated Caspase14(pCasp-14) respectively. (PMID:21567094, 12200134, 10203698, 17515931, 16061209). This antibody can recognise all the forms of Caspase14.

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