Anticorps Polyclonal de lapin anti-CATSPER1

CATSPER1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12722-1-PBS

Synonymes

Cation channel sperm-associated protein 1, CATSPER, hCatSper

---

Galerie de données de validation

• 

  WB analysis using 12722-1-AP (same clone as 12722-1-PBS)

  human testis lysates were subjected to SDS PAGE followed by western blot with 12722-1-AP (CATSPER1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12722-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

12722-1-PBS cible CATSPER1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CATSPER1 Protéine recombinante Ag3417
• Nom complet: cation channel, sperm associated 1
• Masse moléculaire calculée: 780 aa, 90 kDa
• Poids moléculaire observé: 90 kDa
• Numéro d’acquisition GenBank: BC032950
• Symbole du gène: CATSPER1
• Identification du gène (NCBI): 117144
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Cation channel sperm-associated protein 1 (CATSPER1) belongs to a family of four sperm-specific tetrameric voltage-gated cation channels that are highly conserved in humans and mice (PMID: 12402840; 12932298). Definitive evidence that CatSper1 functions as a voltage-gated calcium channel to facilitate hyperactivated sperm motility came from whole-cell patch-clamp measurements of spermatozoa (PMID: 16467839). CATSPER1 channel currents were potentiated in response to intracellular alkalinization, increasing the concentration of intraflagellar calcium and thereby inducing hyperactivity.

{{ptg:RelatedPrimaryAntibodies}}