Anticorps Polyclonal de lapin anti-CCDC23

CCDC23 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30688-1-PBS

Synonymes

SVBP, Coiled coil domain-containing protein 23, Small vasohibin-binding protein

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Galerie de données de validation

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  IHC staining of mouse skin using 30688-1-AP (same clone as 30688-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30688-1-AP (CCDC23 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30688-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skin using 30688-1-AP (same clone as 30688-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30688-1-AP (CCDC23 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30688-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30688-1-PBS cible CCDC23 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CCDC23 Protéine recombinante Ag33650
• Nom complet: coiled-coil domain containing 23
• Numéro d’acquisition GenBank: BC029427
• Symbole du gène: CCDC23
• Identification du gène (NCBI): 374969
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CCDC23 also known as SVBP is a small vasohibin-binding protein of 66 amino acids, and functions as a chaperone of VASH1 in vascular endothelial cells(PMID: 20736312). SVBP enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin(PMID: 29146869, 31171830). Mutations in SVBP cause Neurodevelopmental disorders with ataxia, hypotonia, and microcephaly (NEDAHM)(PMID: 30607023, 31363758).

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