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Anticorps Polyclonal de lapin anti-CCDC88A

CCDC88A Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33569-1-PBS

Synonymes

Akt phosphorylation enhancer, APE, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using CCDC88A Polyclonal antibody (33569-1-AP)

    WB analysis using 33569-1-AP (same clone as 33569-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33569-1-AP (CCDC88A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33569-1-PBS in a different storage buffer formulation.

Informations sur le produit

33569-1-PBS cible CCDC88A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CCDC88A Protéine recombinante Ag37983
Nom complet coiled-coil domain containing 88A
Poids moléculaire observé220 kDa
Numéro d’acquisition GenBankBC132736
Symbole du gène CCDC88A
Identification du gène (NCBI) 55704
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CCDC88A, also named as APE, GRDN and KIAA1212, belongs to the CCDC88 family. CCDC88A enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby it induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation CCDC88A is essential for the integrity of the actin cytoskeleton and for cell migration. It is required for formation of actin stress fibers and lamellipodia. It may be involved in membrane sorting in the early endosome.

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