Anticorps Recombinant de lapin anti-CCL11/Eotaxin

CCL11/Eotaxin Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

243012F8

N° de cat : 98464-1-PBS

Synonymes

C-C motif chemokine 11, Ccl11, Eosinophil chemotactic protein, Eotaxin, Scya11

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98464-1-RR (same clone as 98464-1-PBS)

  1x10^6 HEK-293T cells (left) CCL11/Eotaxin-transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Mouse CCL11/Eotaxin Rabbit RecAb (98464-1-RR, Clone: 243012F8) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98464-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98464-1-RR (same clone as 98464-1-PBS)

  1x10^6 HEK-293T cells (left) or CCL11/Eotaxin-transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Mouse CCL11/Eotaxin Rabbit RecAb (98464-1-RR, Clone: 243012F8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98464-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98464-1-PBS cible CCL11/Eotaxin dans les applications de FC (Intra) et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CCL11/Eotaxin Protéine recombinante Eg2400
• Nom complet: chemokine (C-C motif) ligand 11
• Masse moléculaire calculée: 11kd
• Numéro d’acquisition GenBank: NM_011330
• Symbole du gène: Ccl11
• Identification du gène (NCBI): 20292
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CCL11 also named Eotaxin-1, was initially discovered as an eosinophil-specific chemoattractant. CCL11 plays a central role in both allergic and non-allergic inflammatory reactions by recruiting immune cells such as eosinophils,basophils and Th2 lymphocytes. CCL11 binds to the chemokine receptors CCR2, CCR3 and CCR5, with highest affinity to CCR3. High levels of CCL11 have been described in several chronic inflammatory diseases, such as allergic rhinitis, atopic dermatitis, asthma, gastrointestinal disease and rheumatoid arthritis.

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