Anticorps Recombinant de lapin anti-CCL20/MIP-3 alpha

CCL20/MIP-3 alpha Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

241694B2

N° de cat : 98221-1-PBS

Synonymes

CCL20, MIP-3 Alpha, MIP-3α, CCL 20, C-C motif chemokine 20

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Galerie de données de validation

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  FC experiment of THP-1 using 98221-1-RR (same clone as 98221-1-PBS)

  1x10^6 PMA, LPS and Brefeldin A treated THP-1 cells were intracellularly stained with 0.25 ug Anti-Human CCL20/MIP-3 alpha Rabbit Recombinant Antibody (98221-1-RR, Clone: 241694B2) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated THP-1 cells were intracellularly stained with 0.25 ug Anti-Human CCL20/MIP-3 alpha Rabbit Recombinant Antibody (98221-1-RR, Clone: 241694B2) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98221-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98221-1-PBS cible CCL20/MIP-3 alpha dans les applications de FC (Intra) et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: chemokine (C-C motif) ligand 20
• Masse moléculaire calculée: 11kDa
• Numéro d’acquisition GenBank: NM_004591.3
• Symbole du gène: CCL20/MIP-3 alpha
• Identification du gène (NCBI): 6364
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CCL20, also known as macrophage infiltrating factor protein 3α, is a C-C chemokine that specifically binds to the receptor CCR6. CCL20 is produced in various tissues and by a wide range of immune cells, including neutrophils, natural killer cells, T-helper type 17 (Th17) cells, B cells, and various antigen-presenting cells, such as dendritic cells (DCs), Langerhans cells, and macrophages. Increased expression of CCL20 is likely involved in the increased recruitment of dendritic cells observed in fibroinflammatory diseases such as chronic obstructive pulmonary disease (COPD). CCL20 expression is increased by the proinflammatory cytokine IL-1 beta.

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