Anticorps Monoclonal anti-VCAM-1/CD106

VCAM-1/CD106 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1, kappa

Réactivité testée

Humain

Applications

FC

Conjugaison

PE Fluorescent Dye

Publications(1)

CloneNo.

1.G11B1

N° de cat : PE-65049

Synonymes

VCAM1, VCAM-1, 1.G11B1, CD106, INCAM 100

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Galerie de données de validation

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  FC experiment of HUVEC using PE-65049

  1X10^6 TNF-α stimulated HUVEC cells were surface stained with 10 ul PE Anti-Human CD106 (PE-65049, Clone:1.G11B1) (red) or PE-mouse IgG1 isotype control (black). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: cellules HUVEC,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Applications publiées

• FC: See 1 publications below

Informations sur le produit

PE-65049 cible VCAM-1/CD106 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Mouse / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: s/o
• Nom complet: vascular cell adhesion molecule 1
• Masse moléculaire calculée: 739 aa, 81 kDa
• Numéro d’acquisition GenBank: BC017276
• Symbole du gène: VCAM-1
• Identification du gène (NCBI): 7412
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.1% sodium azide and a stabilizer
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a 110-kDa transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. VCAM1 is expressed by cytokine-activated endothelium, interacts with integrin VLA4 (α4β1) present on the surface of leukocytes, and mediates both adhesion and signal transduction. It is also expressed either constitutively or inducibly in a variety of other cell types, including vascular smooth muscle cells, differentiating skeletal muscle cells, renal and neural epithelial cells, macrophages (Kupffer cells), dendritic cells, and bone marrow stromal cells (PMID: 7507076, 11359843).

Publications

Species	Application	Title
human	FC	J Ethnopharmacol; Jinwu Jiangu Capsule Alleviates Rheumatoid Arthritis Symptoms by Regulating the ADCY10 and cAMP/RANKL Pathways; Authors - Qiuyi Wang

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