Anticorps Recombinant de lapin anti-CD109

CD109 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250327A11

N° de cat : 85924-4-PBS

Synonymes

150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, CD109 antigen, CD109 molecule, CPAMD7

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Galerie de données de validation

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  WB analysis using 85924-4-RR (same clone as 85924-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85924-4-RR (CD109 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85924-4-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 85924-4-RR (same clone as 85924-4-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 85924-4-RR (CD109 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85924-4-PBS in a different storage buffer formulation.

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Informations sur le produit

85924-4-PBS cible CD109 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD109 Protéine recombinante Eg2673
• Nom complet: CD109 molecule
• Masse moléculaire calculée: 162 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_133493.5
• Symbole du gène: CD109
• Identification du gène (NCBI): 135228
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD109, also named as CPAMD7, is a member of the alpha2-macroglobulin/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximately 170kd which is found on the cell surface of platelets, activated T-cells, and endothelial cells. CD109 binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes. Up regulation of CD109 expression has been observed in several different types of tumor.CD109 is a glycosyl-phosphatidylinositol-anchored glycoprotein that is a member of the a2-macroglobulin/C3, C4, C5 family of thioester-containing proteins. There're 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.

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