Anticorps Recombinant de lapin anti-IFNGR1/CD119

IFNGR1/CD119 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241832H4

N° de cat : 98201-1-PBS

Synonymes

IFN-gamma-R-alpha, IFN-gamma-R1, IFN-gamma receptor 1, IFN-gamma R1, CD119

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98201-1-RR (same clone as 98201-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD119 / IFN-gamma R1 Rabbit Recombinant Antibody (98201-1-RR, Clone: 241832H4) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98201-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98201-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98201-1-RR against Mouse CD119 / IFN-gamma R1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98201-1-PBS cible IFNGR1/CD119 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interferon gamma receptor 1
• Masse moléculaire calculée: 52kDa
• Numéro d’acquisition GenBank: NM_010511.3
• Symbole du gène: Ifngr1
• Identification du gène (NCBI): 15979
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)

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