Anticorps Monoclonal anti-CD11b

CD11b Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG2b, kappa

Réactivité testée

Humain, souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

M1/70

N° de cat : 65055-1-PBS

Synonymes

M1/70, Ly 40, Itgam, integrin alpha M, CR3A

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Galerie de données de validation

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  FC experiment of mouse bone marrow cells using 65055-1-Ig (same clone as 65055-1-PBS)

  1X10^6 mouse bone marrow cells were surface stained with 0.2 ug Anti-Mouse CD11b (65055-1-Ig, Clone: M1/70) or 0.2 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 65055-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65055-1-PBS cible CD11b dans les applications de FC et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Rat / IgG2b, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Lymphocytes T spléniques de souris C57BL/10 et splénocytes C57BL/10 activés par la concanavaline A
• Nom complet: integrin alpha M
• Masse moléculaire calculée: 127 kDa
• Numéro d’acquisition GenBank: BC156991
• Symbole du gène: CD11b
• Identification du gène (NCBI): 16409
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

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