Anticorps Recombinant de lapin anti-CD11b

CD11b Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

ICRF44

N° de cat : 65582-1-PBS

Synonymes

ICRF44, CR3A, CR-3 alpha chain, CR 3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha

---

Galerie de données de validation

• 

  FC experiment of human PBMCs using 65582-1-MR (same clone as 65582-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD11b (ICRF44) Mouse IgG2a Recombinant Antibody (65582-1-MR, Clone:ICRF44) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) and PE-conjugated Goat Anti-Mouse IgG. Cells were then stained with APC Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65582-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65582-1-MR (same clone as 65582-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD11b (ICRF44) Mouse IgG2a Recombinant Antibody (65582-1-MR, Clone:ICRF44) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue) and PE-conjugated Goat Anti-Mouse IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65582-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

65582-1-PBS cible CD11b dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Cellules synoviales rhumatoïdes et monocytes humains
• Nom complet: integrin, alpha M (complement component 3 receptor 3 subunit)
• Masse moléculaire calculée: 1152 aa, 127 kDa
• Numéro d’acquisition GenBank: BC096346
• Symbole du gène: CD11b
• Identification du gène (NCBI): 3684
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

{{ptg:RelatedPrimaryAntibodies}}