Anticorps Recombinant de lapin anti-CD11b/c

CD11b/c Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

rat

Applications

FC

Conjugaison

Non conjugué

CloneNo.

OX42

N° de cat : 65606-1-PBS

Synonymes

CD11b, integrin alpha M, Itgam, OX42

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Galerie de données de validation

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  FC experiment of rat bone marrow cells using 65606-1-MR (same clone as 65606-1-PBS)

  1x10^6 rat bone marrow cells were surface stained with 0.25 ug Anti-Rat CD11b/c Mouse IgG2a Recombinant Antibody (65606-1-MR, Clone: OX42) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) and FITC anti-Mouse IgG2a Antibody. Cells were not fixed. This data was developed using the same antibody clone with 65606-1-PBS in a different storage buffer formulation.

• 

  FC experiment of rat bone marrow cells using 65606-1-MR (same clone as 65606-1-PBS)

  1x10^6 rat bone marrow cells were surface stained with 0.25 ug Anti-Rat CD11b/c Mouse IgG2a Recombinant Antibody (65606-1-MR, Clone: OX42) (red) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and FITC anti-Mouse IgG2a Antibody. Cells were not fixed. This data was developed using the same antibody clone with 65606-1-PBS in a different storage buffer formulation.

• 

  FC experiment of rat bone marrow cells using 65606-1-MR (same clone as 65606-1-PBS)

  1x10^6 rat bone marrow cells were surface stained with 0.25 ug Anti-Rat CD11b/c Mouse IgG2a Recombinant Antibody (65606-1-MR, Clone: OX42) (left) or 0.25 ug Anti-Rat CD11b/c (65229-1-Ig, Clone: OX42) (right) and FITC anti-Mouse IgG2a Antibody. Cells were not fixed. This data was developed using the same antibody clone with 65606-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65606-1-PBS cible CD11b/c dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Rat peritoneal macrophages
• Nom complet: integrin alpha M
• Masse moléculaire calculée: 127 kDa
• Numéro d’acquisition GenBank: NM_012711
• Symbole du gène: CD11b
• Identification du gène (NCBI): 25021
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b (integrin alpha M or CR3A) and CD11c (integrin alpha X) are members of the integrin alpha chain family and can form α/β heterodimers with CD18 (integrin β2). CD11b/CD18 is a receptor for the complement protein fragment C3bi, and is also a receptor for fibrinogen, factor X, and ICAM1 (PMID: 2971974; 15485828). CD11c/CD18 acts as a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533). The OX-42 antibody recognizes a common epitope shared between CD11b and CD11c. It binds to C3bi receptor and is known to block C3bi binding (PMID: 3512425; 8449218).

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