Anticorps Recombinant de lapin anti-CD11b

CD11b Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG1

Réactivité testée

rat

Applications

FC

Conjugaison

FITC Plus Fluorescent Dye

CloneNo.

OX42

N° de cat : FITC-65532

Synonymes

integrin alpha M, Itgam, OX42

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Galerie de données de validation

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  FC experiment of rat bone marrow cells using FITC-65532

  1x10^6 rat bone marrow cells were surface stained with 0.2 ug FITC Plus Anti-Rat CD11b (OX42) Mouse Recombinant Antibody (FITC-65532, Clone: OX42), or FITC Plus Mouse IgG1 Isotype Control (MOPC-21) (FITC-65124, Clone: MOPC-21). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: rat bone marrow cells,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-65532 cible CD11b dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Rat peritoneal macrophages
• Nom complet: integrin alpha M
• Masse moléculaire calculée: 127 kDa
• Numéro d’acquisition GenBank: NM_012711
• Symbole du gène: CD11b
• Identification du gène (NCBI): 25021
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

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