Anticorps Monoclonal anti-CD11c

CD11c Monoclonal Antibody for FC

Hôte / Isotype

Armenian Hamster / IgG

Réactivité testée

souris

Applications

IF, FC

Conjugaison

FITC Plus Fluorescent Dye

Publications(7)

CloneNo.

N418

N° de cat : FITC-65130

Synonymes

AI449405, Cd11c, Cr4, integrin alpha X, Itgax, N418

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Galerie de données de validation

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  FC experiment of mouse splenocytes using FITC-65130

  1X10^6 mouse splenocytes were surface stained with APC Anti-Mouse MHC Class II (I-A/I-E) (APC-65122, Clone: M5/114.15.2) and 0.25 ug FITC Plus Anti-Mouse CD11c (FITC-65130, Clone: N418) or 0.25 ug FITC Plus Hamster IgG isotype control. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: splénocytes de souris,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below
• FC: See 6 publications below

Informations sur le produit

FITC-65130 cible CD11c dans les applications de IF, FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Réactivité citée: souris
• Hôte / Isotype: Armenian Hamster / IgG
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Cellules dendritiques de rate de souris
• Nom complet: integrin alpha X
• Numéro d’acquisition GenBank: BC167225
• Symbole du gène: CD11c
• Identification du gène (NCBI): 16411
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).

Publications

Species	Application	Title
mouse	FC	Bioact Mater; Turning foes to friends: Advanced "in situ nanovaccine" with dual immunoregulation for enhanced immunotherapy of metastatic triple-negative breast cancer; Authors - Ze Wang
mouse	FC	Acta Pharm Sin B; Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy; Authors - Renming Fan
mouse	FC	Sci Adv; Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis; Authors - Ran Cheng
mouse	IF	J Adv Res; Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis; Authors - Yi Chen
mouse	FC	J Mater Chem B; PD-1 engineered cytomembrane cloaked molybdenum nitride for synergistic photothermal and enhanced immunotherapy of breast cancer; Authors - Lian Zhu
mouse	FC	Nat Commun; Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity; Authors - Wan-Ru Zhuang

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