Anticorps Recombinant de lapin anti-CD134

CD134 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Biotin

CloneNo.

OX-86

N° de cat : Biotin-FcA65657

Synonymes

Tnfrsf4, Ox40, OX40 antigen, OX40L receptor, Tumor necrosis factor receptor superfamily member 4

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Galerie de données de validation

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  FC experiment of mouse splenocytes using Biotin-FcA65657

  1x10^6 untreated or anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 ug Biotin Anti-Mouse CD134 (OX-86) Rabbit IgG RecAb (Biotin-FcA65657, Clone: OX-86) and PE Streptavidin (Cat.No. PF00021). Cells were then stained with FcZero-rAb™ APC Anti-Mouse CD3e (145-2C11) Rabbit IgG Recombinant Antibody (APC-FcA65651, Clone: 145-2C11). Cells were not fixed.

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  FC experiment of mouse splenocytes using Biotin-FcA65657

  1x10^6 anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 ug Biotin Anti-Mouse CD134 (OX-86) Rabbit IgG RecAb (Biotin-FcA65657, Clone: OX-86) (red) or FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9) (blue), and PE Streptavidin (Cat.No. PF00021). 1x10^6 untreated mouse splenocytes surface stained with 0.25 ug Biotin Anti-Mouse CD134 (OX-86) Rabbit IgG RecAb (Biotin-FcA65657, Clone: OX-86) (black, dashed) and PE Streptavidin (Cat.No. PF00021). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: Anti-CD3/CD28 treated mouse splenocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

Biotin-FcA65657 cible CD134 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: s/o
• Nom complet: tumor necrosis factor receptor superfamily, member 4
• Numéro d’acquisition GenBank: BC065782
• Symbole du gène: CD134
• Identification du gène (NCBI): 22163
• Conjugaison: Biotin
• Excitation/Emission maxima wavelengths: -
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).

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