Anticorps Recombinant de lapin anti-CD134/OX40

CD134/OX40 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241398G7

N° de cat : 98181-1-PBS

Synonymes

TNFRSF4, OX40L receptor, OX40, CD134, ACT35 antigen

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Galerie de données de validation

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  FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

  1x10^6 untreated or PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD4 (RPA-T4) (APC-65143, Clone: RPA-T4). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

  1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98181-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98181-1-RR against Human CD134/OX40 were performed. The affinity constant is 5.48 nM.

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Informations sur le produit

98181-1-PBS cible CD134/OX40 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: tumor necrosis factor receptor superfamily, member 4
• Masse moléculaire calculée: 29 kDa
• Numéro d’acquisition GenBank: NM_003327
• Symbole du gène: CD134
• Identification du gène (NCBI): 7293
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).

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