Anticorps Recombinant de lapin anti-CD134/OX40

CD134/OX40 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242901A7

N° de cat : 98409-2-RR

Synonymes

CD134, Tnfrsf4, Ox40, OX40 antigen, OX40L receptor

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Galerie de données de validation

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  FC experiment of BALB/c mouse splenocytes using 98409-2-RR

  1x10^6 Untreated or CD3/CD28 treated BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD134/OX40 Rabbit RecAb (98409-2-RR, Clone:242901A7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD4 (GK1.5) (APC-65104, Clone: GK1.5). Cells were not fixed.

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  FC experiment of BALB/c mouse splenocytes using 98409-2-RR

  1x10^6 CD3/CD28 treated BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD134/OX40 Rabbit RecAb (98409-2-RR, Clone:242901A7) (red) and PE-Conjugated Goat Anti-Rabbit IgG(H+L), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). 1x10^6 untreated BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD134/OX40 Rabbit RecAb (98409-2-RR, Clone:242901A7) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CD3/CD28 treated BALB/c mouse splenocytes,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98409-2-RR cible CD134/OX40 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD134/OX40 Protéine recombinante Eg2936
• Nom complet: tumor necrosis factor receptor superfamily, member 4
• Masse moléculaire calculée: 30 kDa
• Numéro d’acquisition GenBank: NM_011659.2
• Symbole du gène: CD134
• Identification du gène (NCBI): 22163
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).

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