Anticorps Recombinant de lapin anti-CD134/OX40

CD134/OX40 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

FITC Plus Fluorescent Dye

CloneNo.

241398G7

N° de cat : FITC-98181

Synonymes

TNFRSF4, 241398G7, ACT35, ACT35 antigen, CD134

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Galerie de données de validation

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  FC experiment of human PBMCs using FITC-98181

  1x10^6 untreated or PHA-treated human PBMCs were surface stained with CoraLite® Plus 647 Anti-Human CD4 and 5 ul FITC Plus Anti-Human CD134/OX40 Rabbit RecAb (FITC-98181, Clone: 241398G7). Cells were not fixed.

• 

  FC experiment of human PBMCs using FITC-98181

  1x10^6 PHA-treated human PBMCs were surface stained with 5 ul FITC Plus Anti-Human CD134/OX40 Rabbit RecAb (FITC-98181, Clone: 241398G7)(red) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9) (blue). 1x10^6 untreated human PBMCs were surface stained with 5 ul FITC Plus Anti-Human CD134/OX40 Rabbit RecAb (FITC-98181, Clone: 241398G7) (black, dashed). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: PHA-treated human PBMCs

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-98181 cible CD134/OX40 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD134/OX40 Protéine recombinante Eg1261
• Nom complet: tumor necrosis factor receptor superfamily, member 4
• Masse moléculaire calculée: 29 kDa
• Numéro d’acquisition GenBank: NM_003327
• Symbole du gène: CD134
• Identification du gène (NCBI): 7293
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).

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