- Phare
- Validé par KD/KO
Anticorps Monoclonal anti-CD147
CD147 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain, porc
Applications
WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
1G12B5
N° de cat : 66443-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
66443-1-PBS cible CD147 dans les applications de WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc
Réactivité | Humain, porc |
Hôte / Isotype | Mouse / IgG1 |
Clonalité | Monoclonal |
Type | Anticorps |
Immunogène | CD147 Protéine recombinante Ag2619 |
Nom complet | basigin (Ok blood group) |
Masse moléculaire calculée | 385 aa, 42 kDa |
Poids moléculaire observé | 45-50 kDa |
Numéro d’acquisition GenBank | BC009040 |
Symbole du gène | CD147 |
Identification du gène (NCBI) | 682 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par protéine G |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
CD147, also known as Basigin or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 7812975). The molecule is composed of an intracellular portion, an extracellular portion and a single transmembrane region. CD147 is expressed on a variety of cell types (e.g., hematopoietic, epithelial, and endothelial cells) and at varying levels (PMID: 32968061). Increased expression of CD147 occurs in many tumors. CD147 is a pleiotropic molecule that plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development (PMID: 17945211). CD147 has been identified as a receptor essential for erythrocyte invasion by Plasmodium falciparum (PMID: 22080952). It has been reported that spike protein of SARS-CoV-2 binds to CD147 on host cells, thereby mediating the viral invasion (Wang, Ke, et al, BioRxiv, 2020). The CD147 gene, designated BSG for basigin, is located on chromosome 19p13.3. Four transcript variants encoding different isoforms have been found (PMID: 21536654). CD147 migrates on SDS-PAGE usually between 35 and 65 kDa, depending on the degree of glycosylation (PMID: 17945211).