Anticorps Recombinant de lapin anti-CD155/PVR

CD155/PVR Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240731B1

N° de cat : 98077-1-PBS

Synonymes

Pvr, Tage4, poliovirus receptor, CD155, 240731B1

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Galerie de données de validation

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  FC experiment of mouse thymocytes using 98077-1-RR (same clone as 98077-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) or isotype control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98077-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse thymocytes using 98077-1-RR (same clone as 98077-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98077-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98077-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98077-1-RR against Mouse CD155/PVR were performed. The affinity constant is 0.649 nM.

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Informations sur le produit

98077-1-PBS cible CD155/PVR dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: poliovirus receptor
• Masse moléculaire calculée: 45 kDa
• Numéro d’acquisition GenBank: NM_027514.2
• Symbole du gène: CD155/PVR
• Identification du gène (NCBI): 52118
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD155, also known as the poliovirus receptor (PVR) or Necl-5, is one of the nectin-like family members, belonging to the Ca2+ independent immunoglobulin superfamily (IgSF) in cell adhesion molecules (PMID: 37660884). CD155 is a type I transmembrane protein composed of three extracellular immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. It is involved in cell-to-cell and cell-to-ECM adhesion (PMID: 32019260; 11437656). CD155 acts as a ligand for immune receptors, including TIGIT, CD96 and CD226, which are expressed on T cells and NK cells. CD155 interacts with these receptors to modulate immune responses, such as T cell activation and NK cell-mediated cytotoxicity (PMID: 37660884). CD155 serves as the entry receptor for poliovirus and thereby mediates susceptibility to poliovirus infection (PMID: 15034010).

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