Anticorps Recombinant de lapin anti-CD155/PVR

CD155/PVR Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240731B1

N° de cat : 98077-1-RR

Synonymes

Pvr, Tage4, poliovirus receptor, CD155, 240731B1

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Galerie de données de validation

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  FC experiment of mouse thymocytes using 98077-1-RR

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) or isotype control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG. Cells were not fixed.

• 

  FC experiment of mouse thymocytes using 98077-1-RR

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98077-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98077-1-RR against Mouse CD155/PVR were performed. The affinity constant is 0.649 nM.

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Applications testées

• Résultats positifs en cytométrie: thymocytes de souris,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98077-1-RR cible CD155/PVR dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: poliovirus receptor
• Masse moléculaire calculée: 45 kDa
• Numéro d’acquisition GenBank: NM_027514.2
• Symbole du gène: CD155/PVR
• Identification du gène (NCBI): 52118
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

CD155, also known as the poliovirus receptor (PVR) or Necl-5, is one of the nectin-like family members, belonging to the Ca2+ independent immunoglobulin superfamily (IgSF) in cell adhesion molecules (PMID: 37660884). CD155 is a type I transmembrane protein composed of three extracellular immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. It is involved in cell-to-cell and cell-to-ECM adhesion (PMID: 32019260; 11437656). CD155 acts as a ligand for immune receptors, including TIGIT, CD96 and CD226, which are expressed on T cells and NK cells. CD155 interacts with these receptors to modulate immune responses, such as T cell activation and NK cell-mediated cytotoxicity (PMID: 37660884). CD155 serves as the entry receptor for poliovirus and thereby mediates susceptibility to poliovirus infection (PMID: 15034010).

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