Anticorps Recombinant de lapin anti-CD155/PVR

CD155/PVR Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

PE Fluorescent Dye

CloneNo.

SKII.4

N° de cat : PE-FcA65632

Synonymes

PVR, CD155, HVED, Necl 5, NECL5

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Galerie de données de validation

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  FC experiment of human PBMCs using PE-FcA65632

  1x10^6 human PBMCs were surface stained with 5 ul PE Anti-Human CD155/PVR (SKII.4) Rabbit IgG RecAb (PE-FcA65632, Clone: SKII.4) or PE Rabbit IgG Isotype Control RecAb (PE-FcA98136, Clone: 240953C9). Cells were not fixed.

• 

  FC experiment of human PBMCs using PE-FcA65632

  1x10^6 human PBMCs were surface stained with 5 ul PE Anti-Human CD155/PVR (SKII.4) Rabbit IgG RecAb (PE-FcA65632, Clone: SKII.4) (red) or PE Rabbit IgG Isotype Control RecAb (PE-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

PE-FcA65632 cible CD155/PVR dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: SK-N-AS human neuroblastoma cells
• Nom complet: poliovirus receptor
• Masse moléculaire calculée: 45 kDa
• Numéro d’acquisition GenBank: BC015542
• Symbole du gène: CD155/PVR
• Identification du gène (NCBI): 5817
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection.

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