Anticorps Polyclonal de lapin anti-CD158K/KIR3DL2

CD158K/KIR3DL2 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

Conjugaison

Non conjugué

N° de cat : 33010-1-AP

Synonymes

KIR3DL2, CD158K, MHC class I NK cell receptor, NKAT 4, NKAT4

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Galerie de données de validation

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  WB analysis using 33010-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33010-1-AP (CD158K/KIR3DL2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: NK-92 cells, tissu splénique de souris

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:8000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

33010-1-AP cible CD158K/KIR3DL2 dans les applications de et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CD158K/KIR3DL2 Protéine recombinante Eg4355
• Nom complet: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
• Masse moléculaire calculée: 50 kDa
• Poids moléculaire observé: 50-60 kda
• Numéro d’acquisition GenBank: NM_006737.4
• Symbole du gène: KIR3DL2
• Identification du gène (NCBI): 3812
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

KIR3DL2, also known as CD158k, is an inhibitory receptor expressed by natural killer (NK) cells and a subset of CD8+ T cells. It plays a role in immune regulation by binding to HLA class I molecules, specifically HLA-A3 and HLA-A11, in a peptide-dependent fashion. KIR3DL2 can also function as an innate immune receptor for delivering CpG DNA to TLR9 in NK cells, highlighting its role in both adaptive and innate immunity. This protein is primarily expressed on the cell surface, particularly in NK cells and certain T cells. It has been implicated in various diseases, particularly in the context of hematological malignancies and autoimmune diseases. Aberrant expression of KIR3DL2 has been observed in neoplastic cells in transformed mycosis fungoides and Sézary syndrome, suggesting its potential as a therapeutic target in primary cutaneous anaplastic large-cell lymphoma (pcALCL).

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