Anticorps Monoclonal anti-CD163

CD163 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1, kappa

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

GHI/61

N° de cat : 65169-1-PBS

Synonymes

CD163 molecule, GHI/61, Hemoglobin scavenger receptor, M130, MM130

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Galerie de données de validation

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  FC experiment of human PBMCs using 65169-1-Ig (same clone as 65169-1-PBS)

  1X10^6 human PBMCs were surface stained with 0.5 ug Anti-Human CD163 (65169-1-Ig, Clone:GHI/61) and CoraLite®594-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (red) or unstained. Cells were not fixed. Granulocytes were gated. This data was developed using the same antibody clone with 65169-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65169-1-Ig (same clone as 65169-1-PBS)

  1X10^6 human PBMCs were surface stained with 0.5 ug Anti-Human CD163 (65169-1-Ig, Clone:GHI/61) and CoraLite®594-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 or unstained. Cells were not fixed. Granulocytes were gated. This data was developed using the same antibody clone with 65169-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65169-1-PBS cible CD163 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Préparation de glycoprotéine à partir de rate de leucémie à cellules velues
• Nom complet: CD163 molecule
• Masse moléculaire calculée: 1156 aa, 125 kDa
• Numéro d’acquisition GenBank: BC051281
• Symbole du gène: CD163
• Identification du gène (NCBI): 9332
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD163, also known as M130, is a membrane glycoprotein which belongs to the scavenger receptor superfamily (PMID: 8370408). It is an acute phase-regulated and signal-inducing macrophage protein expressed exclusively in monocytes and tissue macrophages (PMID: 11196644). CD163 mediates endocytosis of haptoglobin-haemoglobin complexes (PMID: 11196644). The uptake of haptoglobin by macrophages contributes to the recycling of iron and also to the inflammatory response (PMID: 22900885). Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity (PMID: 12570164).

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