Anticorps Recombinant de lapin anti-CD163

CD163 Recombinant Antibody for Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Conjugaison

Non conjugué

CloneNo.

240233G5

N° de cat : 83285-2-PBS

Synonymes

M130, sCD163

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Galerie de données de validation

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  Sandwich ELISA standard curve of MP00326-3

  Sandwich ELISA standard curve of MP00326-3, mouse CD163 Recombinant Matched Antibody Pair - PBS only. 83285-1-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard: Eg0794. 83285-2-PBS was HRP conjugated as the detection antibody. Range: 78.1-5000 pg/mL..

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  Sample test of MP00326-3

  For the mouse lung supernatant cultured for 3 days, the mean mouse CD163 concentration was determined to be 154.4 pg/mL in ConA stimulated mouse lung supernatant.

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  Sample test of MP00326-3

  Serum of sixteen mice was measured. The CD163 concentration of detected samples was determined to be 92.2 ng/mL with a range of 46.2-146.5 ng/mL.

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Informations sur le produit

83285-2-PBS cible CD163 dans les applications de Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD163 Protéine recombinante Eg0794
• Nom complet: CD163 antigen
• Masse moléculaire calculée: 121 kDa
• Numéro d’acquisition GenBank: NM_053094.2
• Symbole du gène: Cd163
• Identification du gène (NCBI): 93671
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD163, also known as M130, is a membrane glycoprotein that belongs to the scavenger receptor superfamily (PMID: 8370408). It is an acute phase-regulated and signal-inducing macrophage protein expressed exclusively in monocytes and tissue macrophages (PMID: 11196644). CD163 mediates endocytosis of haptoglobin-haemoglobin complexes (PMID: 11196644). The uptake of haptoglobin by macrophages contributes to the recycling of iron and also to the inflammatory response (PMID: 22900885). Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity (PMID: 12570164).

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