Anticorps Recombinant de lapin anti-CD18

CD18 Recombinant Antibody for FC

Hôte / Isotype

Rat / IgG2a

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

M18/2

N° de cat : 65671-1-PBS

Synonymes

Itgb2, integrin beta 2, LAD, LCAMB, Lfa1

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Galerie de données de validation

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  FC experiment of mouse thymocytes using 65671-1-TR (same clone as 65671-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.5 ug Anti-Mouse CD18 (M18/2) Rat IgG2a RecAb (65671-1-TR, Clone:M18/2) or Rat IgG2a Isotype Control Recombinant Antibody (98427-1-TR, Clone: 250862A1), and FITC anti-Rat IgG2a antibody. Cells were not fixed. This data was developed using the same antibody clone with 65671-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse thymocytes using 65671-1-TR (same clone as 65671-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.5 ug Anti-Mouse CD18 (M18/2) Rat IgG2a RecAb (65671-1-TR, Clone:M18/2) (red) or Rat IgG2a Isotype Control Recombinant Antibody (98427-1-TR, Clone: 250862A1) (blue), and FITC anti-Rat IgG2a antibody. Cells were not fixed. This data was developed using the same antibody clone with 65671-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65671-1-PBS cible CD18 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Rat / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: s/o
• Nom complet: integrin beta 2
• Numéro d’acquisition GenBank: BC145644
• Symbole du gène: CD18
• Identification du gène (NCBI): 16414
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD18, also known as integrin beta-2, is a transmembrane protein that forms heterodimers with CD11a, CD11b, CD11c, CD11d (PMID: 1968349). CD11a/CD18 (LFA-1) is expressed by all leukocytes, while CD11b/CD18 (Mac-1) and CD11c/CD18 (p150,95) are normally restricted to expression on monocytes, macrophages, polymorphonuclear lymphocytes (PMNs), and natural killer cells (PMID: 1968349; 3109455; 10946284). CD18 plays an important role in mediating cell adhesion during immune response and defects of CD18 cause leukocyte adhesion deficiency (PMID: 3594570).

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