Anticorps Recombinant de lapin anti-CD200

CD200 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241346E6

N° de cat : 84244-2-PBS

Synonymes

OX 2, MRC, MOX2, MOX1, CD200 molecule

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Galerie de données de validation

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  WB analysis of human placenta using 84244-2-RR (same clone as 84244-2-PBS)

  human placenta tissue was subjected to SDS PAGE followed by western blot with 84244-2-RR (CD200 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84244-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84244-2-RR

  Biolayer interferometry (BLl) kinetic assays of 84244-2-RR against Human CD200 were performed. The affinity constant is 4.34 nM.

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Informations sur le produit

84244-2-PBS cible CD200 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD200 molecule
• Masse moléculaire calculée: 269 aa, 30 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC022522
• Symbole du gène: CD200
• Identification du gène (NCBI): 4345
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD200, also known as OX2, is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 3032785). It contains two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. CD200 is expressed on a variety of cell types, including thymocytes, B lymphocytes, a subset of T lymphocytes, follicular dendritic cells, neurons, and endothelial cells (PMID: 3032785; 10981966). CD200 binds to its receptor, CD200R, which is primarily expressed by myeloid and T cell lineage (PMID: 15187158). The CD200-CD200R interaction plays a role in immunosuppression and suppression of anti-tumor immune responses (PMID: 22020332).

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