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Anticorps Recombinant de lapin anti-CD200R1

CD200R1 Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

240979B6

N° de cat : 83889-4-PBS

Synonymes

OX2R, Mox2r, CD200R, CD200 receptor 1, 240979B6

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of RAW 264.7 cells using CD200R1 Recombinant antibody (83889-4-RR)

    WB analysis of RAW 264.7 using 83889-4-RR (same clone as 83889-4-PBS)

    RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 83889-4-RR (CD200R1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83889-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83889-4-RR

    Affinity and Kinetic Characterization of 83889-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83889-4-RR against Mouse CD200R1 were performed. The affinity constant is 4.26 nM.

Informations sur le produit

83889-4-PBS cible CD200R1 dans les applications de WB, ELISA et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Protéine recombinante
Nom complet CD200 receptor 1
Masse moléculaire calculée36 kDa
Poids moléculaire observé36 kDa
Numéro d’acquisition GenBankNM_021325.3
Symbole du gène Cd200r1
Identification du gène (NCBI) 57781
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is also called CD200R, CRTR2, MOX2R, and OX2R, and belongs to the CD200R family. CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200R1 is highly glycosylated, containing ten potential N-glycosylation sites (PMID: 15187158). CD200R1 limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. As an immune inhibitory molecule, CD200R1 binds to CD200, ultimately leading to the inhibition of classical activation of macrophages and microglia (PMID: 24588829).

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