Anticorps Recombinant de lapin anti-CD200R1

CD200R1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241453E7

N° de cat : 98155-1-PBS

Synonymes

OX2R, Mox2r, CD200R, CD200 receptor 1, 241453E7

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Galerie de données de validation

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  FC experiment of mouse bone marrow cells using 98155-1-RR (same clone as 98155-1-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse CD200R1 Rabbit Recombinant Antibody (98155-1-RR, Clone: 241453E7) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98155-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse bone marrow cells using 98155-1-RR (same clone as 98155-1-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse CD200R1 Rabbit Recombinant Antibody (98155-1-RR, Clone: 241453E7) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98155-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98155-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98155-1-RR against Mouse CD200R1 were performed. The affinity constant is 3.33 nM.

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Informations sur le produit

98155-1-PBS cible CD200R1 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD200 receptor 1
• Masse moléculaire calculée: 36 kDa
• Numéro d’acquisition GenBank: NM_021325.3
• Symbole du gène: Cd200r1
• Identification du gène (NCBI): 57781
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is also called CD200R, CRTR2, MOX2R, and OX2R, and belongs to the CD200R family. CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200R1 is highly glycosylated, containing ten potential N-glycosylation sites (PMID: 15187158). CD200R1 limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. As an immune inhibitory molecule, CD200R1 binds to CD200, ultimately leading to the inhibition of classical activation of macrophages and microglia (PMID: 24588829).

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