Anticorps Recombinant de lapin anti-CD206

CD206 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250381C1

N° de cat : 98458-3-PBS

Synonymes

CLEC13D, CLEC13DL, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, hMR

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Galerie de données de validation

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  FC experiment of human PBMCs using 98458-3-RR (same clone as 98458-3-PBS)

  1x10^6 GM-CSF, IL-4, and IL-10 treated human PBMCs were surface stained with 0.25 ug Anti-Human MMR/CD206 Rabbit RecAb (98458-3-RR, Clone: 250381C1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human MMR/CD206 Rabbit RecAb (98458-3-RR, Clone: 250381C1) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Monocytes were gated. This data was developed using the same antibody clone with 98458-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98458-3-PBS cible CD206 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD206 Protéine recombinante Eg2428
• Nom complet: mannose receptor, C type 1
• Masse moléculaire calculée: 166 kDa
• Numéro d’acquisition GenBank: NM_002438.4
• Symbole du gène: CD206
• Identification du gène (NCBI): 4360
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

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