Anticorps Recombinant de lapin anti-CD206

CD206 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

IF, FC

Conjugaison

CoraLite® Plus 488 Fluorescent Dye

Publications(1)

CloneNo.

240344D12

N° de cat : CL488-98031

Synonymes

Mrc1, MR, MMR, mannose receptor, C type 1, 240344D12

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Galerie de données de validation

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  FC experiment of mouse peritoneal macrophages using CL488-98031

  1x10^6 mouse peritoneal macrophages were surface stained with APC Anti-Mouse CD107b / LAMP2, and 0.25 ug CoraLite® Plus 488 Anti-Mouse CD206 Rabbit RecAb (CL488-98031, Clone:240344D12) or CoraLite® Plus 488 Rabbit IgG Isotype Control RecAb (CL488-98136, Clone: 240953C9). Cells were incubated with FC Receptor Block prior to staining and fixing. Cells were not fixed.

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  FC experiment of mouse peritoneal macrophages using CL488-98031

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug CoraLite® Plus 488 Anti-Mouse CD206 Rabbit RecAb (CL488-98031, Clone: 240344D12) (red), or CoraLite® Plus 488 Rabbit IgG Isotype Control RecAb (CL488-98136, Clone: 240953C9) (blue). Cells were incubated with FC Receptor Block prior to staining and fixing. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: macrophages péritonéaux de souris

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below
• FC: See 1 publications below

Informations sur le produit

CL488-98031 cible CD206 dans les applications de IF, FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Réactivité citée: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: mannose receptor, C type 1
• Masse moléculaire calculée: 165 kDa
• Numéro d’acquisition GenBank: NM_008625.2
• Symbole du gène: CD206
• Identification du gène (NCBI): 17533
• Conjugaison: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

Publications

Species	Application	Title
mouse	IF,FC	Biomacromolecules; Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing; Authors - Yu Zou

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