Anticorps Polyclonal de lapin anti-CD21

CD21 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24374-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 24374-1-AP (same clone as 24374-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24374-1-AP (CD21 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 24374-1-AP (CD21 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 24374-1-AP (same clone as 24374-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 24374-1-AP (CD21 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24374-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24374-1-PBS cible CD21 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CD21 Protéine recombinante Ag18058
• Nom complet: complement component (3d/Epstein Barr virus) receptor 2
• Masse moléculaire calculée: 1092 aa, 119 kDa
• Poids moléculaire observé: 145 kDa
• Numéro d’acquisition GenBank: BC136394
• Symbole du gène: CD21
• Identification du gène (NCBI): 1380
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD21, also known as complement receptor type 2 (CR2), complement C3d receptor, and Epstein-Barr virus receptor, is a transmembrane protein that contains a small cytoplasmic domain, a transmembrane region and an extracellular domain consisting of 15 tandem short consensus repeat sequences (PMID: 6230668; 2551147). It is expressed on B cells, follicular dendritic cells, thymocytes and a subset of peripheral T cells (PMID: 26119182). CD21 binds complement fragments C3d, C3dg and iC3b and acts as a receptor for the Epstein-Barr virus (PMID: 7753047). On B cells, together with CD19 and CD81, CD21 forms a complex that functions as a co-receptor to the BCR (PMID: 7542009). It is involved in B cells activation and functions.

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