Anticorps Recombinant de lapin anti-CD226

CD226 Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

11A8

N° de cat : 65573-1-PBS

Synonymes

DNAM-1, DNAM1, DNAM 1, CD226 molecule, CD226 antigen

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Galerie de données de validation

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  FC experiment of human PBMCs using 65573-1-MR (same clone as 65573-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD226 Mouse Recombinant Antibody (65573-1-MR, Clone: 11A8) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). Cells were co-stained with CoraLite® Plus 405 Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65573-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65573-1-PBS cible CD226 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Cellules NK humaines
• Nom complet: CD226 molecule
• Masse moléculaire calculée: 336 aa, 39 kDa
• Numéro d’acquisition GenBank: BC074787
• Symbole du gène: CD226
• Identification du gène (NCBI): 10666
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. Stable for one year after shipment.

Informations générales

CD226 (DNAM-1) is a ~65 kDa glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Interactions of CD226 and its ligands, CD155 and CD112, induce NK and T cell-mediated cytotoxicity and cytokine secretion (PMID: 15039383).

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