Anticorps Recombinant de lapin anti-CD268/BAFF-R

CD268/BAFF-R Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242003A1

N° de cat : 98254-1-RR

Synonymes

TNFRSF13C, B-cell-activating factor receptor, BAFF-R, BAFFR, BAFF receptor

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Galerie de données de validation

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  FC experiment of human PBMCs using 98254-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD268/BAFF-R Rabbit Recombinant Antibody (98254-1-RR, Clone: 242003A1) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed.

• 

  FC experiment of human PBMCs using 98254-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD268/BAFF-R Rabbit Recombinant Antibody (98254-1-RR, Clone: 242003A1)(red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98254-1-RR cible CD268/BAFF-R dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: tumor necrosis factor receptor superfamily, member 13C
• Masse moléculaire calculée: 184 aa, 19 kDa
• Numéro d’acquisition GenBank: BC105123
• Symbole du gène: TNFRSF13C
• Identification du gène (NCBI): 115650
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).

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