Anticorps Recombinant de lapin anti-CD268/BAFF-R

CD268/BAFF-R Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

243120H8

N° de cat : 98404-1-PBS

Synonymes

BAFF receptor, Baffr, BAFF-R, B-cell maturation defect, B-cell-activating factor receptor

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98404-1-RR (same clone as 98404-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD19. Cells were not fixed. This data was developed using the same antibody clone with 98404-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98404-1-RR (same clone as 98404-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98404-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98404-1-PBS cible CD268/BAFF-R dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD268/BAFF-R Protéine recombinante Eg1840
• Nom complet: tumor necrosis factor receptor superfamily, member 13c
• Masse moléculaire calculée: 19 kDa
• Numéro d’acquisition GenBank: NM_028075.2
• Symbole du gène: Tnfrsf13c
• Identification du gène (NCBI): 72049
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).

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