Anticorps Monoclonal anti-B7-H3/CD276

B7-H3/CD276 Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG1, kappa

Réactivité testée

souris

Applications

FC

Conjugaison

CoraLite® Plus 405 Fluorescent Dye

CloneNo.

MJ18

N° de cat : CL405-65221

Synonymes

CD276, CD276 antigen, B7RP 2, B7-H3, B7h3

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Galerie de données de validation

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  FC experiment of BALB/c mouse peritoneal macrophages using CL405-65221

  1X10^6 BALB/c mouse peritoneal macrophages were surface stained with 0.5 ug CoraLite® Plus 405 Anti-Mouse CD276 (CL405-65221, Clone: MJ18) or unstained. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: macrophages péritonéaux de souris Balb/c,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL405-65221 cible B7-H3/CD276 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Rat / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Mouse IgG2a Fc-CD276 (aa 1-242) fusion protein
• Nom complet: CD276 antigen
• Numéro d’acquisition GenBank: BC019436
• Symbole du gène: Cd276
• Identification du gène (NCBI): 102657
• Conjugaison: CoraLite® Plus 405 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 399 nm / 422 nm
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD276 (also known as B7-H3) is a type I transmembrane protein expressed on many tissues and cell types. CD276 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, CD276 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).

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