Anticorps Polyclonal de lapin anti-CD2BP2

CD2BP2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Conjugaison

Non conjugué

N° de cat : 32930-1-PBS

Synonymes

CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 Cytoplasmic Tail Binding Protein 2, CD2 tail-binding protein 2, KIAA1178

---

Galerie de données de validation

• 

  WB analysis using 32930-1-AP (same clone as 32930-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32930-1-AP (CD2BP2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32930-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

32930-1-PBS cible CD2BP2 dans les applications de et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CD2BP2 Protéine recombinante Ag38662
• Nom complet: CD2 (cytoplasmic tail) binding protein 2
• Masse moléculaire calculée: 38kDa，341aa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: NM_001243646.1
• Symbole du gène: CD2BP2
• Identification du gène (NCBI): 10421
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD2BP2 (CD2-binding protein 2) is a multifunctional protein that was initially identified as a binding partner of the T-cell surface antigen CD2. It binds to the cytoplasmic tail of CD2 through its C-terminal GYF domain in the cytoplasm, regulating CD2-mediated T-lymphocyte activation. Additionally, CD2BP2 is a component of the U5 small nuclear ribonucleoprotein complex (snRNP), participating in the RNA splicing process. Studies have shown that CD2BP2 plays a crucial role in embryonic development; its absence leads to delayed embryonic growth, vascularization defects, and death by embryonic day 10.5. Specific depletion of CD2BP2 in renal podocytes results in proteinuria and ultimately fatal renal failure.

{{ptg:RelatedPrimaryAntibodies}}