Anticorps Recombinant de lapin anti-CD30/TNFRSF8

CD30/TNFRSF8 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241330A12

N° de cat : 98124-1-RR

Synonymes

CD30, 241330A12, Ki 1 antigen, Ki 1, D1S166E

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Galerie de données de validation

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  FC experiment of human PBMCs using 98124-1-RR

  1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD30 Rabbit Recombinant Antibody (98124-1-RR, Clone: 241330A12) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), 0.25 ug or Isotype Control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (blue). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human CD30 Rabbit Recombinant Antibody (98124-1-RR, Clone: 241330A12) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (black, dashed). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98124-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98124-1-RR against Human CD30 were performed. The affinity constant is 0.528 nM.

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Applications testées

• Résultats positifs en cytométrie: PHA treated human PBMCs,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98124-1-RR cible CD30/TNFRSF8 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: tumor necrosis factor receptor superfamily, member 8
• Masse moléculaire calculée: 64 kDa
• Numéro d’acquisition GenBank: NM_001243
• Symbole du gène: CD30
• Identification du gène (NCBI): 943
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

CD30, also known as TNFRSF8 or Ki-1, is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. It is composed of an extracellular domain with six cysteine-rich repeats, a transmembrane segment, and an intracellular domain (PMID: 1310894). CD30 is expressed on a small subset of activated T and B lymphocytes, and a variety of lymphoid neoplasms, with the highest expression in classical Hodgkin's lymphoma and anaplastic large cell lymphoma (PMID: 9826579; 28885612). The CD30 ligand (CD30L or CD153) is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily (PMID: 8701986). Signal transduction of CD30/CD30L utilizes signal transducers, TNFR-associated factors (TRAF1, 2, 3 and 5) (PMID: 9826579).

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