Anticorps Recombinant de lapin anti-CD31

CD31 Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

WM-59

N° de cat : 65614-1-PBS

Synonymes

EndoCAM, GPIIA, GPIIA', PECA1, PECAM 1

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Galerie de données de validation

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  FC experiment of human PBMCs using 65614-1-MR (same clone as 65614-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD31 (WM-59) Mouse IgG2a Recombinant Antibody (65614-1-MR, Clone: WM-59) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) and PE-conjugated Goat Anti-Mouse IgG. Cells were then stained with APC Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65614-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65614-1-MR (same clone as 65614-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD31 (WM-59) Mouse IgG2a Recombinant Antibody (65614-1-MR, Clone: WM-59) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue) and PE-conjugated Goat Anti-Mouse IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65614-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65614-1-PBS cible CD31 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: s/o
• Nom complet: platelet/endothelial cell adhesion molecule
• Masse moléculaire calculée: 83 kDa
• Numéro d’acquisition GenBank: BC022512
• Symbole du gène: CD31
• Identification du gène (NCBI): 5175
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD31, also known as PECAM1 (Platelet endothelial cell adhesion molecule), is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. It is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, CD31 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).

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