Anticorps Recombinant de lapin anti-CD314/NKG2D

CD314/NKG2D Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

1D11

N° de cat : 65643-1-PBS

Synonymes

KLRK1, CD314, 1D11, KLR, Killer cell lectin-like receptor subfamily K member 1

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Galerie de données de validation

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  FC experiment of human PBMCs using 65643-1-MR (same clone as 65643-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD314/NKG2D (1D11) Mouse IgG2a Recombinant Antibody (65643-1-MR, Clone:1D11) or Mouse IgG2a Isotype Control, and PE-conjugated Goat Anti-Mouse IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human CD8 (UCHT4) Mouse IgG2a Recombinant Antibody. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65643-1-PBS in a different storage buffer formulation.

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  FC experiment of human PBMCs using 65643-1-MR (same clone as 65643-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD314/NKG2D (1D11) Mouse IgG2a Recombinant Antibody (65643-1-MR, Clone:1D11) (red) or Mouse IgG2a Isotype Control (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65643-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65643-1-PBS cible CD314/NKG2D dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Lignée cellulaire NKL
• Nom complet: killer cell lectin-like receptor subfamily K, member 1
• Masse moléculaire calculée: 25 kDa
• Numéro d’acquisition GenBank: BC039836
• Symbole du gène: KLRK1
• Identification du gène (NCBI): 22914
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD314, also known as NKG2D or Killer cell lectin-like receptor subfamily K member 1 (KLRK1), is a type II lectin-like transmembrane stimulatory receptor (PMID: 8436421). In humans, it is expressed on NK cells, gamma delta T cells, and CD8+ alpha beta T cells (PMID: 10426993). Various families of cell surface ligands have been identified, including the MICA/MICB and ULBP proteins (PMID: 12150888). CD314 is involved in both innate and adaptive immunities, and the NKG2D/NKG2DL pathway involves multiple effector cell types for controlling tumor progression (PMID: 31720075).

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