Anticorps Recombinant de lapin anti-E-cadherin

E-cadherin Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242018A7

N° de cat : 98323-1-PBS

Synonymes

242018A7, Cadherin-1, CD324, Cdh1, E-Cad/CTF1

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Galerie de données de validation

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  FC experiment of PC-12 using 98323-1-RR (same clone as 98323-1-PBS)

  1x10^6 PC-12 cells were surface stained with 0.25 ug Anti-Rat E-cadherin Rabbit RecAb (98323-1-RR, Clone: 242018A7) (red),or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue)and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98323-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98323-1-PBS cible E-cadherin dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: E-cadherin Protéine recombinante Eg1229
• Nom complet: cadherin 1
• Masse moléculaire calculée: 99 kDa
• Numéro d’acquisition GenBank: NM_031334.1
• Symbole du gène: Cdh1
• Identification du gène (NCBI): 83502
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.

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