Anticorps Monoclonal anti-CD324 (E-cadherin)

CD324 (E-cadherin) Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG1, kappa

Réactivité testée

canin, Humain, souris

Applications

FC

Conjugaison

CoraLite® Plus 750 Fluorescent Dye

CloneNo.

DECMA-1

N° de cat : CL750-65241

Synonymes

AA960649, cadherin 1, Cdh1, Ecad, L CAM, Um, UVO



Applications testées

Résultats positifs en cytométriecellules MDCK,

Dilution recommandée

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL750-65241 cible CD324 (E-cadherin) dans les applications de FC et montre une réactivité avec des échantillons canin, Humain, souris

Réactivité canin, Humain, souris
Hôte / Isotype Rat / IgG1, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène Mouse embryonal carcinoma cell line PCC4 Aza RI
Nom complet cadherin 1
Numéro d’acquisition GenBankBC098501
Symbole du gène Cdh1
Identification du gène (NCBI) 12550
Conjugaison CoraLite® Plus 750 Fluorescent Dye
Excitation/Emission maxima wavelengths755 nm / 780 nm
Forme Liquide
Méthode de purification Purification par affinité
Tampon de stockage PBS with 0.09% sodium azide.
Conditions de stockageStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.

Protocole

Product Specific Protocols
FC protocol for CL Plus 750 CD324 (E-cadherin) antibody CL750-65241Download protocol
Standard Protocols
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