Anticorps Polyclonal de lapin anti-CD35

CD35 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30057-1-PBS

Synonymes

KN, CR1, Complement receptor type 1, C3BR, C3b/C4b receptor

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Galerie de données de validation

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  WB analysis using 30057-1-AP (same clone as 30057-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30057-1-AP (CD35 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30057-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30057-1-PBS cible CD35 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CD35 Protéine recombinante Ag30243
• Nom complet: complement component (3b/4b) receptor 1 (Knops blood group)
• Masse moléculaire calculée: 224 kDa
• Poids moléculaire observé: 250 kDa
• Numéro d’acquisition GenBank: NM_000573
• Symbole du gène: CR1
• Identification du gène (NCBI): 1378
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD35, also known as complement receptor type 1 (CR1) or C3b/C4b receptor, is a single-chain glycoprotein consisting of 30 repeating homologous protein domains known as short consensus repeats (~60 amino acids each) followed by transmembrane and cytoplasmic domains (PMID: 8765013). CD35 is variably expressed by granulocytes, monocytes, B cells, some T cells, erythrocytes, follicular dendritic cells, Langerhans cells, and glomerular podocytes (PMID: 19004497). CD35 acts as a receptor for C3b and C4b and plays important roles in the regulation of the complement cascade and clearance of immune complexes. A soluble form of CD35 has been found in plasma (PMID: 3156931). It has been reported that soluble CD35 is produced by a proteolytic cleavage in the C-terminal region of CD35 transmembrane domain (PMID: 9405292).

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